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目的:探讨HCV基因型同肝病严重程度的关系,研究HCV基因型同疾病治疗的关系,为丙肝诊断和治疗提供理论依据。方法:选取抗-HCV阳性患者的血清标本190份作HCV、RNA检验与HCV的基因分型。结果:HCV基因型与患者肝病严重程度相关,尤其是1b型肝硬化及肝癌比例高于其他基因型;1b型基因病毒应答率显著低于2a型,P<0.05,差异有统计学意义。结论:HCV基因型同肝病严重程度关系密切,并对抗病毒治疗影响重大。HCV基因分型对于患者的诊断及治疗具有重要指导意义。
Objective: To investigate the relationship between HCV genotypes and the severity of liver diseases, and to study the relationship between HCV genotypes and disease treatment, so as to provide a theoretical basis for the diagnosis and treatment of hepatitis C. Methods: Totally 190 serum samples from patients with anti-HCV were selected for HCV and RNA test and HCV genotyping. Results: The genotype of HCV was correlated with the severity of liver disease, especially the proportion of type 1b cirrhosis and hepatocellular carcinoma was higher than that of other genotypes. The response rate of type 1b genotype was significantly lower than that of type 2a (P <0.05). The difference was statistically significant. Conclusion: The genotype of HCV is closely related to the severity of liver disease and has a significant impact on anti-virus treatment. HCV genotyping has important guiding significance for the diagnosis and treatment of patients.