观察了不同剂量的四逆汤 (SND)及相同剂量的四逆汤灌胃后不同时点的大鼠血浆及心肌组织内皮素 (ET)浓度的变化。末次药后 1h腹腔注射垂体后叶素 (Pit) 15u/kg ,Pit注射后 1h取材 ,分别测定心肌及血浆ET浓度。结果四逆汤灌胃的最佳剂量为 5 0g/kg体重·d ,最佳灌胃时间为 5天 ;SND组心肌及血浆ET浓度明显低于缺血组 ,说明SND可显著降低缺血心肌ET浓度 ,并对血浆ET浓度有降低趋势。 The changes of endothelin (ET) in plasma and myocardial tissue at different time points after different doses of SND and the same dose of SND were observed. After the last drug, the pituitary pituitin (Pit) 15u/kg was intraperitoneally injected at 1h and was harvested 1h after Pit injection. Myocardial and plasma ET concentrations were measured. Results The optimal dose of SND was intragastric administration was 50 g/kg body weight·day, and the best time of gavage was 5 days. The myocardial and plasma ET levels in SND group were significantly lower than that in ischemic group, indicating that SND can significantly reduce ischemic myocardium. ET concentration, and plasma ET concentration has a decreasing trend.