接种乙型肝炎疫苗已公认是预防乙型肝炎的重要措施。然而,对接种乙型肝炎疫苗后保护性抗体水平持续多长时间及何时需要再接种疫苗,至今尚无定论。先前的研究认为,全程免疫后抗-HBs水平持续高于10IU/L(最低保护性水平)可达5年左右,但是几项不同的乙型肝炎疫苗接种试验的长期随访结果表明,抗-HBs水平通常降到低于最低保护性水平甚至消失。作者发现800名健康者接种乙型肝炎疫苗后,起初抗-HBs水平高于10IU/L者在第1次接种后1年有3%降到10 Vaccination of hepatitis B vaccine has been recognized as an important measure to prevent hepatitis B. However, the duration of protective antibody levels after vaccination with hepatitis B vaccine and the time required for re-vaccination remains to be determined. Previous studies suggest that anti-HBs levels persist above 10 IU / L (minimum protective level) for up to 5 years after full immunization, but the long-term follow-up of several different hepatitis B vaccination trials suggests that anti-HBs The level usually falls below the minimum protective level or even disappears. The authors found that 800 healthy people were vaccinated with hepatitis B vaccine, the initial anti-HBs levels higher than 10IU / L 1 year after the first vaccination 3% to 10