目的:探讨急性重症胰腺炎(SAP)综合治疗疗效。方法:对近5 a来收治的45例急性重症胰腺炎的临床资料进行回顾性分析。结果:非手术治疗治愈24例,死亡5例,治愈率为82.8%;手术治疗治愈12例,死亡4例,治愈率为75.0%。结论:重视SAP的综合治疗,针对患者不同病因、病情及不同病期适时调整治疗对策,采用相应的个体化治疗措施是治疗SAP成功的关键。 Objective: To investigate the treatment of acute severe pancreatitis (SAP). Methods: The clinical data of 45 cases of severe acute pancreatitis admitted in the recent 5 years were analyzed retrospectively. Results: In non-surgical treatment, 24 cases were cured and 5 cases died. The cure rate was 82.8%. 12 cases were cured by surgery and 4 cases died. The cure rate was 75.0%. Conclusions: It is important to pay attention to the comprehensive treatment of SAP and to adjust the treatment strategy according to the different etiology, condition and different stages of patients timely. The corresponding individualized treatment measures are the key to the success of SAP.