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目的 :探讨肾结石患者红细胞膜Ca2 + -Mg2 + -ATP酶 (Ca2 + -Mg2 + -ATPase)的活性变化与肾结石发生发展的相互关系。方法 :参照Shalev法检测 2 5名正常人和 30例肾结石患者红细胞膜Ca2 + -Mg2 + -ATPase活性 ;采用原子吸收火焰法测定红细胞内Ca2 + 和Mg2 + 浓度 ,并进行比较分析。结果 :肾结石患者红细胞膜Ca2 + -Mg2 + -ATPase活性明显增加 ,与正常对照组比较有显著性差异 (P <0 .0 1) ;而其红细胞内Ca2 + 含量明显下降 ,Mg2 + 含量则明显升高 (P均 <0 .0 1)。结论 :肾结石患者红细胞膜Ca2 + -Mg2 + -ATPase活性异常增加可能是导致或加速肾结石发生发展的原因之一。
Objective: To investigate the relationship between the activity of Ca2 + -Mg2 + -ATPase (Ca2 + -Mg2 + -ATPase) and the occurrence and development of renal calculus in patients with kidney stones. Methods: The Ca2 + -Mg2 + -ATPase activity of erythrocyte membrane in 25 normal subjects and 30 patients with nephrolithiasis was detected by Shalev’s method. The concentrations of Ca2 + and Mg2 + in erythrocytes were measured by atomic absorption flame method and compared. Results: The activity of Ca2 + -Mg2 + -ATPase in erythrocyte membrane was significantly increased in patients with kidney stones compared with the normal control group (P <0.01), while the content of Ca2 + in erythrocytes was significantly decreased while the content of Mg2 + Was significantly higher (P <0.01). Conclusion: Abnormal increase of Ca2 + -Mg2 + -ATPase in the erythrocyte membrane in patients with kidney stones may be one of the reasons leading to or accelerating the development of kidney stones.