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目的：观察危重患者抗生素相关性肠炎与抗生素使用的之间的关系。方法选择2013年3月至2014年4月入我院接受治疗的危重症患者80例，观察其临床表现、实验室检验、危险因素以及治疗情况等。结果80例患者中11例患者并发抗生素相关性肠炎。11例患者进行抗生素治疗的一联、二联、三联以及≥四联的使用存在显著差异，具有统计学意义，P<0.05.结论危重症患者在治疗时联用抗生素种类越多，抗生素相关性肠炎出现的概率越大，因此危重患者在治疗过程中应该慎重选择抗生素种类的使用。“,”Objective: To investigate the relationship between the use of criticaly il patients with antibiotic associated colitis and antibiotics. Methods:March,2013 to April,2014 80 criticaly il patients admitted in our hospital, observed the clinical manifestations, laboratory examination, risk factors and treatment. etc.. Results:11 patients of 80 with antibiotic associated colitis. 11patients were significant differences of antibiotic treatment of a joint, two, more than triple and quadruple use, with statistical significance, P<0.05.Conclusion:Criticaly il associated with more kinds of antibiotic in the treatment, the probability of antibiotic associated colitis is bigger, so antibiotics should be carefuly chosen.