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目的探讨非血缘及HLA配型不全相合造血干细胞移植在白血病治疗中的应用。方法非血缘脐血移植治疗儿童白血病3例,非血缘异基因外周血造血干细胞移植治疗白血病1例,HLA配型不全相合外周血造血干细胞移植治疗白血病1例。结果5例患者完全植入,+15～+25天白细胞(WBC)>1.0×109/L,+35～+51天血小板(Plt)>20×109/L。例1出现急性移植物抗宿主病(aGVHD)Ⅰ度;例4aGVHDⅣ度;例5出现肝静脉闭塞综合征(VOD)、aGVHDⅠ度、出血性膀胱炎(HC);例2移植后6个月复发,放弃治疗死亡;余4例正常生活或工作。结论非血缘及HLA配型不全相合造血干细胞移植治疗白血病是安全有效的。
Objective To investigate the application of non-blood-associated and HLA-matched incompatible hematopoietic stem cell transplantation in the treatment of leukemia. Methods Non - blood cord blood transplantation in children with leukemia in 3 cases, non - allogeneic peripheral blood stem cell transplantation in the treatment of leukemia in 1 case, HLA matching incompatible peripheral blood stem cell transplantation in the treatment of leukemia in 1 case. Results Five patients were completely implanted. The WBC> 1.0 × 109 / L for + 15 ~ + 25 days and the Plt> 20 × 109 / L for + 35 ~ + 51 days. Case 1 appeared acute graft-versus-host disease (aGVHD) Ⅰ degree; case 4aGVHD Ⅳ degree; Case 5 appeared hepatic vein occlusion syndrome (VOD), aGVHD Ⅰ degree, hemorrhagic cystitis (HC); Example 2 6 months after transplantation recurrence , Give up the treatment of death; more than 4 cases of normal life or work. Conclusion It is safe and effective to treat non-hematologic and HLA mismatched hematopoietic stem cell transplantation for leukemia.