含去甲基化 Cp G基序的合成寡脱氧核苷酸 ( ODN)可引发以 B细胞、自然杀伤细胞和单核 /巨噬细胞激活为特点的免疫应答。有证据表明 ,Cp G基序可增强 DNA疫苗的免疫原性 ,作者将含 Cp G基序的 ODN及其互补序列插入 p UC系列载体—— p Bluescript KS的 Eco R V和 Eco R I位点 , Synthetic oligodeoxynucleotides (ODNs), which contain a demethylated CpG motif, elicit an immune response characterized by activation of B cells, natural killer cells, and monocytes / macrophages. There is evidence that the CpG motif enhances the immunogenicity of DNA vaccines. The authors inserted the ODN containing the CpG motif and its complement into the EcoR V and Eco R I sites of the pUC series vector, p Bluescript KS,