子痫前期(PE)是妊娠期特发性疾病,其病因和发病机制至今仍未完全阐明。近年来有研究表明PE患者的胎盘和血循环中存在一些微小RNAs(microRNA,miRNA)与正常妊娠者存在显著性差异表达,这些miRNA的靶标可能与子痫前期的发病机制相关,如miR-210、miR-155、miR-18b与胎盘缺血、缺氧相关;miR-152、miR-19a、miR-182、miR-181a与免疫因素有关。研究PE相关miRNA及其对靶标的调控可能有助于阐明PE的发病机制。 Preeclampsia (PE) is an idiopathic disease of pregnancy, the etiology and pathogenesis has not yet been fully elucidated. In recent years, studies have shown that there are some microRNAs (miRNAs) in the placenta and blood circulation of PE patients, which are significantly different from those in normal pregnancy. The targets of these miRNAs may be related to the pathogenesis of preeclampsia, such as miR-210, miR-155, miR-18b are associated with placental ischemia and hypoxia; miR-152, miR-19a, miR-182 and miR-181a are related to immune factors. Studying PE-related miRNAs and their regulation of targets may help elucidate the pathogenesis of PE.