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目的观察并对比乳酸左氧氟沙星/头孢唑肟在急性水肿型胆源性胰腺炎治疗中的效果,为急性胰腺炎的临床规范抗感染治疗提供参考。方法选取2014年1月至2014年11月期间在本院急诊科病区连续收治的180例急性水肿型胆源性胰腺炎患者,随机分为乳酸左氧氟沙星治疗组与头孢唑肟治疗组,在禁食水、胃肠减压、抑酸、抑酶、营养支持等常规治疗基础上分别选用乳酸左氧氟沙星及头孢唑肟抗感染,监测患者呕吐、腹痛、腹胀缓解情况及时间,开放饮食时间,住院天数,血常规、C反应蛋白(CRP)、生化、血清淀粉酶变化及影像学胰腺炎症吸收情况。结果乳酸左氧氟沙星治疗组总有效率高于头孢唑肟治疗组(P<0.05);与头孢唑肟治疗组比较,乳酸左氧氟沙星治疗组呕吐、腹痛、腹胀缓解时间缩短(P<0.01),开放饮食时间提前,住院天数缩短(P<0.05),血常规、CRP及血淀粉酶恢复正常时间均提前(P<0.05),影像学胰腺炎症吸收快(P<0.05)。结论在急性水肿型胆源性胰腺炎抗感染治疗中,乳酸左氧氟沙星效果优于头孢唑肟。
Objective To observe and compare the effect of levofloxacin lactate / ceftizoxime in the treatment of acute edematous biliary pancreatitis and provide a reference for the clinical norms of anti-infective treatment of acute pancreatitis. Methods One hundred and eighty patients with acute edematous biliary pancreatitis who were consecutively admitted to our hospital emergency department from January 2014 to November 2014 were randomly divided into levofloxacin treatment group and ceftizoxime treatment group, Fresh water, gastrointestinal decompression, acid suppression, aprotinin, nutritional support and other conventional treatment were selected based on levofloxacin lactate and ceftizoxime anti-infection, monitoring patients with vomiting, abdominal pain, abdominal distension and relief of time, open diet time, hospital stay , Blood routine, C-reactive protein (CRP), biochemistry, serum amylase and imaging pancreas inflammation absorption. Results The total effective rate of levofloxacin-treated group was higher than that of ceftizoxime-treated group (P <0.05). Compared with ceftizoxime treatment group, levofloxacin lactate treatment group had shorter vomiting, abdominal pain and bloating duration (P <0.01) The days of hospitalization were shortened (P <0.05), the levels of blood routine, CRP and amylase returned to normal earlier (P <0.05), and the imaging pancreatic inflammation absorbed faster (P <0.05). Conclusion Levofloxacin lactate is superior to ceftizoxime in the treatment of acute edematous biliary pancreatitis.