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观测西宁地区不同类型肾小球疾患者的血浆心房肽（ＡＮＰ）和醛固酮（Ａｌｄ）水平变化。方法：用放射免疫法观测６４例病人，并与本地区健康人群对比；结果：尿毒症组ＡＮＰ、Ａｌｄ水平明显高于对照组（Ｐ＜０．００１），急、慢性肾炎ＡＮＰ、Ａｌｄ水平明显高于对照组（Ｐ＜０．０５～０．０１），肾病综合征者ＡＮＰ也显著低于对照组（Ｐ＜０．０５），而Ａｌｄ无明显差异。治疗后（尿毒症除外），急性肾炎，肾病综合征ＡＮＰ、Ａｌｄ下降更多，而慢性肾炎Ａｌｄ升高、ＡＮＰ无变化。尿毒症以及治疗前的急性肾炎、肾病综合征的ＡＮＰ与Ａｌｄ呈显著正相关，治疗后尿钠水平与ＡＮＤ、Ａｌｄ呈负相关，除尿毒症者ＡＮＰ、Ａｌｄ与ＢＵＮ呈正相关外，余各型肾炎／病的ＡＮＰ、Ａｌｄ与ＢＵＮ、血浆蛋白、尿蛋白等均无相关。结论：上述变化除与疾病本身特点有关外，还可能与低氧环境有关。
To observe the changes of plasma atrial natriuretic peptide (ANP) and aldosterone (Ald) in different types of patients with glomerulopathy in Xining area. Methods: 64 patients were observed by radioimmunoassay and compared with healthy people in this area. Results: The levels of ANP and Ald in uremia group were significantly higher than those in control group (P <0.001). The levels of ANP and Ald in acute and chronic nephritis were significantly higher (P <0.05 ~ 0.01), nephrotic syndrome ANP was significantly lower than the control group (P <0.05), while Ald was no significant difference. After treatment (except uremia), acute nephritis, nephrotic syndrome ANP, Ald decreased more, and chronic nephritis Ald increased, ANP no change. Uremia and acute nephritis before treatment, nephrotic syndrome ANP and Ald has a significant positive correlation between the level of urinary sodium after treatment and AND, Ald was negative, except for uremia ANP, Ald and BUN was positive, Nephritis / sick ANP, Ald and BUN, plasma protein, urinary protein, etc. were not related. Conclusion: In addition to the above changes in the characteristics of the disease itself, but also may be related to hypoxic environment.