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目的:探讨强化降脂方案对老年原发性高血压患者血脂、炎性细胞因子及动脉弹性参数指标水平的影响。方法:研究对象选取我院2014年3月-2015年12月收治老年原发性高血压患者共50例,以随机数字表法分为对照组(25例)和观察组(25例),分别给予瑞舒伐他汀单用和在此基础上加用普罗布考辅助治疗,比较两组患者治疗前后甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C)、胱抑素C(Cys-C)、C反应蛋白(CRP)、动脉僵硬度、压力应变弹性系数、顺应性、增大指数、脉搏波传导速度及不良反应发生率等。结果:观察组患者治疗后血脂指标水平均显著优于对照组、治疗前;观察组患者治疗Cys-C和CRP水平均显著低于对照组、治疗前;观察组患者治疗后动脉弹性参数指标水平均显著优于对照组、治疗前;同时两组患者不良反应发生率比较差异无统计学意义。结论:强化降脂方案治疗老年原发性高血压可有效缓解症状体征,改善血脂水平,抑制局部炎性反应,提高动脉弹性,且未增加不良反应发生风险。
Objective: To investigate the effects of intensive lipid-lowering regimen on serum lipids, inflammatory cytokines and arterial elasticity parameters in elderly patients with essential hypertension. Methods: A total of 50 elderly patients with essential hypertension were selected from March 2014 to December 2015 in our hospital. The patients were randomly divided into control group (n = 25) and observation group (n = 25) Given rosuvastatin alone and on this basis plus probucol adjuvant therapy, compared two groups of patients before and after treatment triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL-C), low LDL-C, Cys-C, C-reactive protein (CRP), arterial stiffness, stress-strain elasticity, compliance, increase index, pulse wave velocity and adverse reactions Rate and so on. Results: The levels of serum lipids in the observation group were significantly better than those in the control group before treatment. The levels of Cys-C and CRP in the observation group were significantly lower than those in the control group before treatment. The indexes of arterial elasticity in the observation group after treatment Were significantly better than the control group before treatment; while the incidence of adverse reactions in both groups was no significant difference. Conclusion: Fortified lipid-lowering regimen can effectively alleviate the symptoms and signs, improve the level of blood lipid, restrain the local inflammatory reaction, increase the arterial elasticity without increasing the risk of adverse reactions.