环丙沙星的抗生素后效应和抗生素后亚MIC效应

来源 :中国医院药学杂志 | 被引量 : 0次 | 上传用户:zhang5658
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方法:采用稀释法消除抗生素,测定体外环丙沙星对肺炎克雷白菌、绿脓杆菌临床分离菌株的PAE、PASME。结果:环丙沙星在8、16MIC两个药物浓度下对肺炎克雷白菌的PAE为6.6±1.3h,7.2±1.5h;绿脓杆菌的临床分离菌株的PAE分别为:7.8±0.8h,8.5±0.6h。环丙沙星对绿脓杆菌的PAE稍长于对肺炎克雷白菌的PAE,相同浓度的抗生素对同一菌株的PASME长于PAE Methods: The antibiotics were eliminated by dilution method, and the PAE and PASME of Ciprofloxacin and Pseudomonas aeruginosa isolates in vitro were determined. Results: PAE of Ciprofloxacin against Corynebacterium pneumoniae in Ciprofloxacin at the concentrations of 8 and 16MIC were 6.6 ± 1.3h and 7.2 ± 1.5h, respectively. The PAE of clinically isolated strains of Pseudomonas aeruginosa were As follows: 7.8 ± 0.8h, 8.5 ± 0.6h. The PAE of ciprofloxacin against Pseudomonas aeruginosa was slightly longer than PAE against Klebsiella pneumoniae, PASME of the same concentration of antibiotics against the same strain was longer than that of PAE
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