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方法：采用稀释法消除抗生素，测定体外环丙沙星对肺炎克雷白菌、绿脓杆菌临床分离菌株的ＰＡＥ、ＰＡＳＭＥ。结果：环丙沙星在８、１６ＭＩＣ两个药物浓度下对肺炎克雷白菌的ＰＡＥ为６．６±１．３ｈ，７．２±１．５ｈ；绿脓杆菌的临床分离菌株的ＰＡＥ分别为：７．８±０．８ｈ，８．５±０．６ｈ。环丙沙星对绿脓杆菌的ＰＡＥ稍长于对肺炎克雷白菌的ＰＡＥ，相同浓度的抗生素对同一菌株的ＰＡＳＭＥ长于ＰＡＥ
Methods: The antibiotics were eliminated by dilution method, and the PAE and PASME of Ciprofloxacin and Pseudomonas aeruginosa isolates in vitro were determined. Results: PAE of Ciprofloxacin against Corynebacterium pneumoniae in Ciprofloxacin at the concentrations of 8 and 16MIC were 6.6 ± 1.3h and 7.2 ± 1.5h, respectively. The PAE of clinically isolated strains of Pseudomonas aeruginosa were As follows: 7.8 ± 0.8h, 8.5 ± 0.6h. The PAE of ciprofloxacin against Pseudomonas aeruginosa was slightly longer than PAE against Klebsiella pneumoniae, PASME of the same concentration of antibiotics against the same strain was longer than that of PAE