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为了探讨静脉丙种球蛋白 (IVG)预防及治疗早产儿感染的价值 ,用单向免疫琼脂扩散法检测 52例出生 1～ 3天的早产儿血清IgG、IgA、IgM。结果显示IgG均值随胎龄增加而增高 (r =0 99,P <0 0 1 ) ,而IgG、IgM差异无显著意义 ,故胎龄越小越有应用静脉丙种球蛋白 (IVIG)的指征。另外选同期患儿 30例 ,参考相似孕周、体重及日龄 ,随机分为IVIG组和对照组各 1 5例 ,均选用同类抗生素 ,且不用其它免疫制剂及血浆治疗 ,IVIG组按每日 0 5～ 1g kg稀释成 50ml在 2～ 3小时内静脉滴注 ,首次用后 2～ 3天 ,重复一次 ,连用 2次。IVIG组治疗一周后IgG均值从 8 3g L升到1 3 6g L(P <0 0 1 )而对照组治疗后IgG均值仅为 6 7g L提示 :早产儿重症感染时用IVIG疗效十分满意
In order to investigate the value of intravenous gamma globulin (IVG) in the prevention and treatment of preterm infant infection, the serum IgG, IgA and IgM of 52 preterm infants born 1-3 days were detected by one-way immunogold agar diffusion assay. The results showed that IgG mean increased with gestational age (r = 0 99, P 0 01), while IgG and IgM had no significant difference. Therefore, the smaller the gestational age, the more the application of intravenous gamma globulin (IVIG) . In addition, 30 children of the same period were enrolled in this study. According to the similar gestational age, body weight and age, 15 cases were randomly divided into IVIG group and control group, all of which were treated with the same antibiotics, without other immune agents and plasma treatment. 0 5 ~ 1g kg diluted to 50ml within 2 to 3 hours intravenously, after the first use of 2 to 3 days, repeated once, once every 2 times. After one week of IVIG treatment, the average IgG value increased from 83g to 136gL (P <0.01), while the control group had a mean IgG value of only 67g after treatment. Tip: IVIG treatment is very satisfactory for severe infection in preterm infants