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耐药伤寒菌株日趋增加并在南方一些局部地区暴发流行,是现代伤寒的一大特征。近年各地防疫部门大量的流行病学资料显示,90%以上患者为M_1型耐氯霉素株感染,由于其耐药性可通过R质粒介导大肠杆菌传递,易使耐药菌短期激增,同时改变了机体对菌株的反应性,使临床经过复杂多变,仅有10.5%具有稽留热、缓脉、玖瑰疹、无欲貌及肝脾大五个典型表现。多数人热程长、症状重、并发症多或呈潜隐经过而以合并症或并发症表现为主诉,病死率达2～5%之多。常规抗菌药物不易奏
The increasing incidence of drug-resistant typhoid strains and outbreaks in some southern areas is a major feature of modern typhoid fever. In recent years, epidemic prevention departments around the large number of epidemiological data show that more than 90% of patients with M_1-resistant chloramphenicol resistant strains, due to its resistance through the R plasmid-mediated E. coli transmission, easy to make short-term surge in resistant bacteria, at the same time Changed the body’s reactivity to strains, the clinical complex and changeable, only 10.5% with the retention of heat, slow pulse, Jiu Ruan, no desire appearance and five typical liver and spleen performance. The majority of long-range fever, symptoms, complications or latent after the complications or complications of the main complaint, the mortality rate of up to 2 to 5%. Conventional anti-bacterial drugs are not easy to play