Electronic skins(e-skins)with an excellent sensing performance have been widely developed over the last few decades.However,wearability,biocompatibility,environmental friendliness and scalability have become new limitations.Self-healing ability can improve the long-term robustness and reliability of e-skins.However,self-healing ability and integration are hardly balanced in classical structures of self-healable devices.Here,cellulose nanofiber/poly(vinyl alcohol)(CNF/PVA),a biocompatible moisture-inspired self-healable composite,was applied both as the binder in functional layers and the substrate.Various functional layers comprising particular carbon mate-rials and CNF/PVA were patterned on the substrate.A planar structure was beneficial for integration,and the active self-healing ability of the functional layers endowed self-healed e-skins with a higher tough-ness.Water served as both the only solvent throughout the fabrication process and the trigger of the self-healing process,which avoids the pollution and bioincompatibility caused by the application of noxious additives.Our e-skins could achieve real-time monitoring of whole-body physiological signals and environmental temperature and humidity.Cross-interference between different external stimuli was suppressed through reasonable material selection and structural design.Combined with conventional electronics,data could be transmit-ted to a nearby smartphone for post-processing.This work provides a previously unexplored strategy for multifunctional e-skins with an excellent practicality.