论文部分内容阅读
本文介绍一种用高效液相色谱法测定干滴血中的氯喹和去乙基氯喹浓度的方法。测定受治患者体液内的氯喹浓度,将有助于识别由疟原虫抗性所致的,或由于药物剂量不足所致的治疗失败。挑选28名一个月内未服过氯喹,镜检恶性疟原虫血症为640—18500/mm~3(均值为1400/mm~3)的坦桑尼亚儿童为研究对象。年龄7～14岁。治疗的第一和第二天给服氯喹碱基10mg/kg,第三天为5mg/kg。用毛细
This article describes a method for the determination of chloroquine and de-chloroquine concentrations in dry-blood drops by high performance liquid chromatography. Determining the concentration of chloroquine in the body fluid of a subject to be treated will help to identify treatment failures caused by Plasmodium resistance or due to inadequate drug dosage. A total of 28 Tanzanian children who did not receive chloroquine within one month and who had P. falciparum microscopic examination of 640-18500 / mm 3 (mean, 1400 / mm 3) were selected as study subjects. Age 7 to 14 years old. On the first and second days of treatment, chlorpromazine 10 mg / kg was administered and on the third day 5 mg / kg. Use capillaries