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目的探讨慢性丙型肝炎患者HCV-RNA载量与ALT、AST、AST/ALT比值的相关性。方法选取慢性丙型肝炎患者144例,运用实时荧光定量PCR技术检测患者血浆HCV-RNA载量,速率法检测血清中ALT、AST活性。结果随着HCV-RNA载量的升高,ALT、AST、AST/ALT比值增高,经相关性分析,HCV-RNA载量与ALT、AST、AST/ALT之间存在正相关性,相关系数分别为0.49、0.75、0.57,均P<0.05。结论慢性丙型肝炎患者的HCV-RNA载量与ALT、AST、AST/ALT之间存在正相关性,通过HCV-RNA载量结合AST、ALT、AST/ALT比值,可以提高检测的灵敏度。
Objective To investigate the relationship between HCV-RNA load and ALT, AST and AST / ALT in chronic hepatitis C patients. Methods A total of 144 patients with chronic hepatitis C were enrolled in this study. The plasma HCV-RNA load was detected by real-time fluorescence quantitative PCR. The serum ALT and AST activities were measured by the rate method. Results The ratio of ALT, AST and AST / ALT increased with the increase of HCV-RNA load. Correlation analysis showed that there was a positive correlation between HCV-RNA load and ALT, AST and AST / ALT 0.49,0.75,0.57, all P <0.05. Conclusions There is a positive correlation between HCV-RNA load and ALT, AST and AST / ALT in patients with chronic hepatitis C, and the sensitivity of detection can be improved by combining HCV-RNA load with AST, ALT and AST / ALT ratio.