论文部分内容阅读
目的:探讨生长激素(GH)与狼疮性肾炎(LN)的关系。方法:采用放射免疫分析法(RIA)检测52例LN患者和30例健康体检者血清GH水平。结果:LN组血清GH水平明显高于正常对照组(P<0.05);活动期LN组GH水平显著高于静止期LN组(P<0.05);52例LN患者血清GH水平与抗ds-DNA水平呈正相关(r=0.713,P<0.05)。结论:LN患者血清GH水平与病情活动有关,可将GH作为判断LN病情活动性的指标之一;GH在LN发病中可能起一定的作用。
Objective: To investigate the relationship between growth hormone (GH) and lupus nephritis (LN). Methods: Serum GH levels were measured by radioimmunoassay (RIA) in 52 patients with LN and 30 healthy subjects. Results: The serum GH level in LN group was significantly higher than that in normal control group (P <0.05). The GH level in active LN group was significantly higher than that in quiescent LN group (P <0.05) The level was positively correlated (r = 0.713, P <0.05). CONCLUSIONS: Serum GH levels in patients with LN are related to their disease activity. GH may be used as an indicator of LN activity. GH may play a role in the pathogenesis of LN.