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1977年,Gruntzig首次在人体用非手术方法作冠状动脉腔内成型术,用特制的气囊导管经导引管插入冠状动脉近端狭窄处,注入50％泛影葡胺使气囊扩张,造成4～6个大气压,历数秒钟,重复数次,直至梗阻减轻,表现为通过狭窄段的压力下降减小,或造影显示管径增宽。此后,积累了200余例的经验,不仅引起医务界,亦引起了公众的广泛兴趣。
In 1977, Gruntzig for the first time in human non-surgical coronary angioplasty, with a special balloon catheter through the guide tube into the proximal coronary stenosis, injection of 50% diatrizoate to balloon expansion, resulting in 4 ~ Six atmospheres, for a few seconds, are repeated several times until the obstruction is relieved, manifested by a decrease in pressure across the stenosis, or angiography showing a broadening of the diameter. Since then, accumulated more than 200 cases of experience, not only aroused the medical profession, has also aroused widespread public interest.