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在胚胎或胎盘发育的特殊时期进行营养控制,尽管不会对胚胎的重量产生影响,但可以导致胚胎器官发育过程中的实质性改变。尤其是使营养素受限制幼仔的肾脏和脂肪量发生了较大的定向改变,同时瘦素,胰岛素样生长因I/II和糖皮质激素受体的mRNA水平增高。对幼仔时期的营养素限制,会使刚成年大鼠出现心血管的压力反射变迟钝。交感神经刺激血清瘦素水平增加,这在对照组是不会出现的,这说明了脂肪细胞应激对敏感性的恢复。总之,对早期发育时期的营养素整体限制,一定形式上改变了成年鼠的生理状况,说明了如果再给予相应的环境刺激则会对后期疾病产生诱导作用。
Nutritional control at a particular stage of the embryo or placenta development, although not affecting the weight of the embryo, can result in substantial changes in the development of the organ of the embryo. In particular, there is a large directional change in the kidney and fat mass in nutrient-restricted pups, while leptin, insulin-like growth are attributed to elevated mRNA levels of I / II and glucocorticoid receptors. Nutritional limitations in young pups cause cardiovascular pressure reflexes in young adults to become retarded. Sympathetic stimulation of serum leptin levels increased, which in the control group will not appear, indicating the sensitivity of adipocyte stress recovery. In conclusion, the overall limitation on nutrients during the early developmental stages will certainly change the physiological status of adult mice, indicating that if given the appropriate environmental stimuli will have an induction of late disease.