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[目的]比较中成药康艾注射液联合5-氟脲嘧啶(5-FU)、奥沙利铂与单用化疗治疗晚期大肠癌的临床疗效。[方法]晚期大肠癌患者,随机分为治疗组(康艾注射液加化疗)、对照组(化疗)。均治疗4~6个疗程,观察临床疗效、生活质量和不良反应以及生存率和中位生存期。[结果]治疗组改善生活质量和不良反应明显优于对照组(P<0.05),但2组临床疗效及1、2、3年生存率和中位生存期方面比较差异无统计学意义(P>0.05)。[结论]康艾注射液可明显改善晚期大肠癌患者的生活质量和减少化疗药物不良反应。
[Objective] To compare the clinical efficacy of Chinese medicine Kangai injection combined with 5-fluorouracil (5-FU), oxaliplatin and chemotherapy alone in the treatment of advanced colorectal cancer. [Methods] Patients with advanced colorectal cancer were randomly divided into treatment group (Kangai injection plus chemotherapy) and control group (chemotherapy). Treatment of 4 to 6 courses, observe the clinical efficacy, quality of life and adverse reactions and survival and median survival. [Results] The quality of life and adverse reactions of the treatment group were significantly better than those of the control group (P <0.05), but there was no significant difference between the two groups in the clinical curative effect and the 1, 2, 3 year survival rate and the median survival time (P > 0.05). [Conclusion] Kangai injection can significantly improve the quality of life of patients with advanced colorectal cancer and reduce adverse reactions of chemotherapy drugs.