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目的:探讨舒芬太尼联合丙泊酚用于无痛人流的效果和安全性。方法:选择2009年1月～12月在天津市第四医院自愿接受无痛人工流产的健康妇女300例,随机分为舒芬太尼配伍丙泊酚静脉麻醉组100例(A组)、芬太尼配伍丙泊酚静脉麻醉组100例(B组)、曲马多联合利多卡因组100例(C组)。观察A、B两组丙泊酚的用量、并比较3组的镇痛效果、宫颈松弛情况、术中出血量及不良反应。结果:A组与B组在丙泊酚用量上有统计学差异(P<0.05)。在镇痛效果上,A组优于B组和C组,差异有统计学意义。在宫颈松弛方面,A组可顺利通过6.5号宫颈扩张器,与B组比较,差异无统计学意义(P>0.05),而与C组比较差异有统计学意义(P<0.01)。3组术中出血量比较差异无统计学意义(P>0.05)。结论:舒芬太尼联合丙泊酚行无痛人流是安全、有效的镇痛方法,值得临床推广。
Objective: To investigate the efficacy and safety of sufentanil combined with propofol for painless abortion. Methods: A total of 300 healthy women who volunteered for painless induced abortion at the Fourth Hospital of Tianjin from January 2009 to December 2009 were randomly divided into sufentanil group (n = 100) and propofol intravenous anesthesia group (n = 100) 100 patients (group B) received intravenous anesthesia with propofol and 100 patients (group C) received tramadol plus lidocaine. The dosage of propofol in group A and group B was observed. The analgesic effect, cervical relaxation, intraoperative blood loss and adverse reactions were compared between the three groups. Results: There was a significant difference in the dosage of propofol between group A and group B (P <0.05). In the analgesic effect, A group is superior to B group and C group, the difference was statistically significant. In cervical relaxation, group A could successfully pass cervical dilator 6.5, which was not significantly different from that of group B (P> 0.05), but was significantly different from that of group C (P <0.01). There was no significant difference between the three groups in the amount of bleeding (P> 0.05). Conclusion: Sufentanil combined with propofol in painless abortion is a safe and effective analgesic method, which is worthy of clinical promotion.