缺氧缺血性脑损伤(HIBD)是以脑损伤为主的多脏器损害性疾病,包括心脏、肝脏、肾脏、肾上腺、胃肠道等脏器,病情重,病死率高,但目前国内外有关HIBD文献资料多以脑组织损伤为主,对于其多脏器损伤鲜有报道。为此,我们选用优质新生7 d Wistar大鼠,制造HIBD模型,检测不同时间肾脏组织SOD、MDA的变化来观察HIBD多脏器损害的结果,并期望能以此提供临床依据,指导临床治疗。 Hypoxic-ischemic brain damage (HIBD) is a multi-organ damaging disease mainly including brain injury, including heart, liver, kidney, adrenal gland, gastrointestinal tract and other organs. The disease is severe and the mortality rate is high. However, Most of the literature about HIBD is mostly brain tissue damage, rarely reported for its multiple organ damage. To this end, we selected high-quality newborn 7-day Wistar rats to make HIBD model to detect the changes of SOD and MDA in kidney tissue at different time to observe the results of HIBD multiple organ damage and hope to provide clinical basis to guide clinical treatment.