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醛固酮逃逸现象是指在血管紧张素Ⅱ转化酶抑制剂(angiotensinconvertingenzymeinhibitor,ACEI)应用过程中,血浆醛固酮水平在短期内下降,长期治疗后仍可增高的现象。慢性心力衰竭醛固酮合成和释放增加。钠潴留、电解质紊乱,脂质胶原沉积和纤维化,导致慢性心力衰竭进行性加重。螺内酯的化学结构类似醛固酮,能阻断醛固酮作用。显著降低心力衰竭的总病死率和(或)住院时间,拮抗心律失常,新的选择性醛固酮拮抗剂可作为心力衰竭、高血压病和心肌梗死后强适应症推荐药物。
Aldosterone escaping is the phenomenon of plasma aldosterone levels decreasing in the short term during angiotensin-converting enzyme inhibitor (ACEI) use and increasing after prolonged treatment. Increased aldosterone synthesis and release in chronic heart failure. Sodium retention, electrolyte imbalance, lipid collagen deposition and fibrosis, leading to progressive worsening of chronic heart failure. Spironolactone chemical structure similar to aldosterone, can block the role of aldosterone. Significantly reduce the overall mortality and / or hospital stay of heart failure and antagonize cardiac arrhythmias. The new selective aldosterone antagonists are recommended as strong indications for heart failure, hypertension and post-MI.