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目的:主要研究胃癌局部浸润的记忆性T细胞、树突状细胞和细胞毒性T淋巴细胞与患者预后的关系。方法:选取60例胃癌组织蜡块,用免疫组化方法检测胃癌局部浸润的记忆性T细胞、树突状细胞和细胞毒性T淋巴细胞的数量及分布,分析局部免疫活性细胞与胃癌患者临床病理特征及预后的关系。结果:胃癌局部免疫活性细胞高表达者,淋巴结转移率较低。单因素分析显示,淋巴结转移、肿瘤直径、TNM分期、肿瘤组织局部浸润的记忆性T细胞、细胞毒性T淋巴细胞和树突状细胞及免疫细胞联合表达是胃癌患者预后的影响因素。多因素分析显示,淋巴结转移和记忆性T细胞是胃癌患者预后的独立影响因素。结论:胃癌局部浸润的免疫活性细胞可以很好地预示淋巴结的转移情况。胃癌局部浸润的记忆性T细胞对判断患者的预后有一定意义。
Objective: To study the relationship between the local infiltration of memory T cells, dendritic cells and cytotoxic T lymphocytes in gastric cancer and their prognosis. Methods: 60 cases of gastric cancer tissue were selected for paraffin section. The number and distribution of locally infiltrating T-cell, dendritic cell and cytotoxic T lymphocyte in gastric cancer were detected by immunohistochemistry. The clinicopathological features of local immunocompetent cells and gastric cancer Characteristics and prognosis of the relationship. Results: The high expression of local immunocompetent cells in gastric cancer showed a lower lymph node metastasis rate. Univariate analysis showed that lymph node metastasis, tumor diameter, TNM stage, tumor tissue local infiltration of memory T cells, cytotoxic T lymphocytes and dendritic cells and immune cells combined expression of prognostic factors in patients with gastric cancer. Multivariate analysis showed that lymph node metastasis and memory T cells were independent prognostic factors in patients with gastric cancer. Conclusion: Local infiltration of gastric cancer immunocompetent cells can well predict the lymph node metastasis. Local memory of gastric cancer T cells to determine the prognosis of patients with a certain significance.