目的:评价还原型谷胱甘肽与丹参注射液用于治疗胆汁淤积型药物性肝炎患者的临床疗效。方法:选取消化内科2014年1月—2015年1月间收治的胆汁淤积型药物性肝炎患者84例,将其分为观察组和对照组,各42例,对照组患者给予还原型谷胱甘肽治疗,观察组患者另在对照组治疗基础上辅加丹参注射液治疗,评价两组患者治疗后的总有效率和治疗前后肝功能指标的变化以及不良反应的发生情况。结果:观察组患者治疗后的总有效率为97.62%显著高于对照组为83.33%(P<0.05);两组患者治疗后ALT、AST、ALP、TBA肝功能指标低于治疗前(P<0.05),观察组患者的下降幅度优于对照组(P<0.05);两组患者用药后均无明显不良反应的发生。结论:还原型谷胱甘肽与丹参注射液联用治疗胆汁淤积型药物性肝炎患者的临床疗效优于单用还原型谷胱甘肽治疗。 Objective: To evaluate the clinical efficacy of reduced glutathione and salvia miltiorrhiza injection in patients with cholestatic drug-induced hepatitis. Methods: Eighty-four patients with cholestasis-type drug-induced hepatitis were selected from January 2014 to January 2015 in the Department of Gastroenterology. They were divided into observation group and control group, 42 cases in each. Patients in the control group were treated with reduced glutathione Peptide treatment, the other patients in the observation group were additionally treated with Salviae Miltiorrhizae injection on the basis of the control group, and the total effective rate and the changes of liver function indexes before and after treatment and the occurrence of adverse reactions in the two groups were evaluated. Results: The total effective rate of the observation group was 97.62%, which was significantly higher than that of the control group (83.33%, P <0.05). The indexes of liver function of ALT, AST, ALP and TBA after treatment in both groups were lower than those before treatment (P < 0.05). The decline rate of observation group was better than that of control group (P <0.05). No adverse reactions occurred in both groups after treatment. Conclusion: The clinical efficacy of reduced glutathione and Salvia miltiorrhiza injection in treating patients with cholestatic drug-induced hepatitis is better than that of reducing glutathione alone.