以Ｎ－ｒａｓ癌基因突变作为急性髓细胞白血病（ＡＭＬ）的分子标志，用ＰＣＲ技术研究该病的微量残留白血病细胞（ＭＲＬＣ）．１２例缓解期患者中检测到４例有Ｎ－ｒａｓ癌基因突变，对１０例患者作动态观察发现２例突变一直存在，２例在病程中发生突变。因此，Ｎ－ｒａｓ癌基因突变可用于检测ＭＲＬＣ． The N-ras oncogene mutation as a molecular marker of acute myeloid leukemia (AML), the use of PCR technology to study the disease trace residual leukemia cells (MRLC). In 12 patients with remission, 4 cases were detected with N-ras oncogene mutations, 10 cases of patients with dynamic observation found that 2 cases of mutations have been present, 2 cases of mutations in the course of disease. Therefore, N-ras oncogene mutations can be used to detect MRLC.