由于目前对重症病人采用了多种支持生命的先进系统治疗,多系统器官衰竭(MSOF)综合征已成为临床上的一种疾病。肝功能不全是 MSOF 综合征的主要组成部份,并合并感染和高的死亡率。多数作者认为单纯的组织低灌注和缺氧,不能引起这些损坏。最近认为,单核巨噬细胞对肺、肾实质的损坏,是多器官衰竭的一个病因。肝细胞与巨噬性 Kupffer 细胞的接触,可能是 MSOF 综合证中肝功能不全的病理机制。为此,本文作者作了动物实验。其方法是将鼠肝经无钙液灌注和胶原酶(梭菌肽 Due to the current state of the art in treating multiple critically ill patients with advanced life-support systems, MSOF syndrome has become a clinical condition. Hepatic insufficiency is a major component of MSOF syndrome and is associated with infection and high mortality. Most authors believe that simple tissue hypoperfusion and hypoxia can not cause these damages. Recently, mononuclear macrophages that damage the lung and kidney parenchyma are one of the causes of multiple organ failure. Contact of hepatocytes with macrophage Kupffer cells may be the pathological mechanism of hepatic insufficiency in the MSOF syndrome. To this end, the author of this article made animal experiments. The method is to rat liver by calcium-free perfusion and collagenase (Clostridial peptide