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目的:探讨研究手术中缓释氟尿嘧啶对大肠癌患者的治疗效果和安全性,以供临床治疗大肠癌给予参考.方法:以2009年2月~2011年10月我院收治的大肠癌患者62例为临床研究对象,随机分为两组,对照组患者在根治性手术后使用氟尿嘧啶联合生理盐水冲洗腹腔并保留,实验组患者植入缓释氟尿嘧啶,患者手术后4周内开始化疗,观察比较疗效和安全性.结果:两组患者不良反应比较,p >0.05,差异无统计学意义;实验组患者2年生存率高于对照组,局部复发率低于对照组,p 0.05, the difference was not statisticaly significant; 2-year survival rate of the experimental group were higher than that in control group, the local recurrence rate was lower than the control group (p <0.05), the difference was statisticaly significant. Conclusion: sustained release fluorouracil can reduce the local recurrence rate in patients to improve 2-year survival rate of patients placed in patients with colorectal cancer surgery is a better treatment.