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目的探讨反应停治疗多发性骨髓瘤(multiplemyeloma,MM)的初步疗效。方法11例MM患者,应用反应停起始剂量50mg/d～200mg/d,每2周增加50mg/d～200mg/d直到患者不能耐受。根据患者情况决定伍用化疗。据血M蛋白减少情况判断疗效,分为完全缓解(completeremission,CR)、接近完全缓解(nearlycompleteremissionNCR)、很好的部分缓解(verygoodpartialresponse,VGPR)、部分缓解(partialresponse,PR)、微小反应(minimalresponse,MR)和无反应(non-response,NR)。同时观察贫血、骨髓浆细胞百分比和其他指标的变化。结果NCR3例,VGPR2例,PR5例,总有效率为90.9%。无不能耐受的毒副作用。结论反应停可作为初发或难治MM的治疗选择。
Objective To investigate the preliminary therapeutic effect of response to multiple myeloma (MM). Methods 11 patients with MM, the initial response dose of 50mg / d ~ 200mg / d, every 2 weeks increased 50mg / d ~ 200mg / d until the patient can not tolerate. According to the patient’s condition decided to use chemotherapy. According to the reduction of blood M protein to determine the efficacy, divided into complete remission (CR), nearly complete remission (nearly complete remissionNCR), very good partial remission (veryGoodpartialresponse, VGPR), partial response (PR), minimal response (minimalresponse, MR) and non-response (NR). At the same time observe the changes of anemia, the percentage of bone marrow plasma cells and other indicators. Results NCR 3 cases, VGPR 2 cases, PR 5 cases, the total effective rate was 90.9%. Nothing can tolerate the side effects. Conclusion Response to stop treatment can be used as a treatment of initial or refractory MM.