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目的探讨2011-2013年福建省肿瘤医院麻醉性镇痛药品的使用趋势,为麻醉药品的科学管理及合理用药提供参考。方法采用限定日剂量(DDD)测定药品的利用单位,通过用药频度(DDDs)分析用药情况。根据药品用量和DDDs的排序,对该院麻醉性镇痛药品的使用情况进行回顾性分析。结果对各药品的DDDs进行排序,发现2011—2013年DDDs排序前2位的药品基本不变,在DDDs绝对值上主要是盐酸羟考酮控释片(40 mg)2013年较2012年有较大增长,以及小剂量羟考酮控释片(5 mg、10 mg)出现环比上升。芬太尼贴剂(2片)、盐酸羟考酮控释片(40 mg)和硫酸吗啡缓释片(30 mg)3年中DUI均大于2;而盐酸哌替啶3年中的DUI均小于0.5;其余药品的DUI接近1。吗啡注射剂和可待因片剂3年中的B/A值均大于1;盐酸羟考酮控释片(5 mg、10 mg、40 mg)B/A值均≤1。结论肿瘤医院对麻醉性镇痛药品的使用逐渐趋于合理,今后仍需重视推行使用新剂型(如芬太尼透皮贴剂、盐酸羟考酮缓释片),并注意加强各类镇痛药品的使用特点宣教,做到合理正确使用药品以及发现其不良反应,最大程度地提高癌症患者的生活质量。
Objective To explore the trend of using narcotic analgesics in Cancer Hospital of Fujian Province from 2011 to 2013 and provide references for the scientific management and rational drug use of narcotic drugs. Methods DDD was used to determine the utilization units of drugs, and drug consumption was analyzed by DDDs. According to the quantity of drugs and the order of DDDs, the use of narcotic analgesics in the hospital was retrospectively analyzed. Results The DDDs of each drug were ranked and found that the top two DDDs in 2011-2013 ranked the same, the absolute value of DDDs was mainly oxycodone hydrochloride controlled release tablets (40 mg) in 2013 compared with 2012 Large increases, as well as low-dose oxycodone controlled-release tablets (5 mg, 10 mg) showed a sequential increase. The DUI of fentanyl patch (2 tablets), oxycodone hydrochloride controlled-release tablets (40 mg) and morphine sustained-release tablets (30 mg) were both greater than 2 in 3 years; while the DUI in 3 years of meperidine hydrochloride Less than 0.5; the rest of the drug’s DUI close to 1. The B / A value of morphine injection and codeine was greater than 1 in 3 years. The B / A values of oxycodone hydrochloride controlled release tablets (5 mg, 10 mg, 40 mg) were all less than 1. Conclusion The use of narcotic analgesics in Tumor Hospital gradually becomes more reasonable. In the future, new dosage forms (such as fentanyl transdermal patches and oxycodone hydrochloride sustained-release tablets) should still be emphasized. Attention should also be paid to various types of analgesics The characteristics of the use of medicines mission, so that the proper and proper use of drugs and found that adverse reactions, to maximize the quality of life of cancer patients.