慢性乙型肝炎肝组织B7-1表达与α-干扰素近期疗效的关系

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目的 了解慢性乙型肝炎 (CHB)肝组织B7- 1表达与α -干扰素 (α -IFN)近期疗效的关系。方法 对 6 8例使用α -IFN的CHB患者治疗前行肝组织活检 ,采用免疫组织化学方法观察其B7- 1的表达。结果  6 8例CHB中 45例 (6 6 2 % )B7- 1表达阳性 ,5例正常人肝组织无表达。α -IFN的总应答率 ,肝组织B7- 1表达阳性组为 6 6 7% (30 /4 5 ) ,阴性组为 39 1% (9/2 3) ,二者差异显著 (χ2 =7 2 0 ,P <0 0 1)。随B7- 1阳性表达程度的增强 ,肝组织炎性活动积分 (HAI)及血清丙氨酸转氨酶 (ALT)异常值明显增加。结论 肝组织B7- 1表达水平可能是预测α -IFN近期疗效的重要参数之一。 Objective To investigate the relationship between the expression of B7-1 in chronic hepatitis B (CHB) liver and the short-term efficacy of interferon-α (IFN-α). Methods Sixty-eight patients with CHB treated with α -IFN were biopsied for liver biopsy, and the expression of B7-1 was observed by immunohistochemistry. Results The positive expression of B7 - 1 was found in 45 cases (66.2%) of CHB in 68 cases, and no expression in 5 normal liver tissues. The total response rate of α-IFN was 67.7% (30/45) in the group of positive expression of B7-1 and 39.1% (9/2 3) in the group of negative, and the difference was significant (χ2 = 7 2 0, P <0 0 1). With the increase of B7-1 positive expression, the abnormality of HAI and ALT increased obviously. Conclusion The expression level of B7-1 in liver tissue may be one of the important parameters to predict the short-term effect of α-IFN.
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