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目的 了解肺炎克雷伯菌的流行状况及产生耐药性的危险因素。方法 采取回顾性调查研究来分析以前应用抗生素与肺炎克雷伯菌产生耐药性的相关性及肺炎克雷伯菌的流行状况。结果 1999年 3月 1日至 2 0 0 0年 8月 31日我院住院的 36 179例患者中有 16 9例感染了肺炎克雷伯菌 (感染率为0 4 7% ) ,其中 16 6例 (株 )至少对一种抗生素产生耐药性 ,且 15 4例 (株 )对两种以上的抗生素产生了耐药性。肺炎克雷伯菌对氨苄西林、哌拉西林、头孢噻吩、氨苄西林 /舒巴坦、头孢哌酮、头孢唑啉、头孢呋肟、复方新诺明、妥布霉素、庆大霉素、氨曲南、头孢噻肟、头孢曲松、头孢他啶、头孢吡肟、环丙沙星、替卡西林 /克拉维酸、阿米卡星、头孢西丁、哌拉西林 /他唑巴坦和依米配能的耐药率分别是 98%、77%、6 4%、6 0 %、5 9%、5 7%、5 5 %、5 1%、5 1%、5 0 %、4 9%、4 9%、4 9%、4 7%、4 7%、4 6 %、4 6 %、4 4%、38%、2 2 %和 0。结论 以前应用抗生素治疗与肺炎克雷伯菌对之产生耐药性明显相关 ,而且大多数菌株对多种抗生素耐药。
Objective To understand the prevalence of Klebsiella pneumoniae and its risk factors for drug resistance. Methods The retrospective investigation was conducted to analyze the correlation between the antibiotic resistance of Klebsiella pneumoniae previously developed and the drug resistance of Klebsiella pneumoniae and the prevalence of Klebsiella pneumoniae. Results Of the 36 179 patients hospitalized in our hospital from March 1, 1999 to August 31, 2000, 16 9 were infected with Klebsiella pneumonia (infection rate was 0 47%), of which 16 6 In one case, at least one antibiotic was found to be drug-resistant, and 154 (strains) were resistant to two or more antibiotics. Klebsiella pneumoniae was resistant to ampicillin, piperacillin, cefalotin, ampicillin / sulbactam, cefoperazone, cefazolin, cefuroxime, cotrimoxazole, tobramycin, gentamicin, Aztreonam, cefotaxime, ceftriaxone, ceftazidime, cefepime, ciprofloxacin, ticarcillin / clavulanic acid, amikacin, cefoxitin, piperacillin / tazobactam and The resistance rates of rice to energy were 98%, 77%, 64%, 60%, 59%, 57%, 55%, 51%, 51%, 50%, 49% 49%, 49%, 47%, 47%, 46%, 46%, 44%, 38%, 22% Conclusions Previous antibiotic treatment was significantly associated with the development of resistance to Klebsiella pneumoniae, and most strains were resistant to multiple antibiotics.