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目的观察国产脂质体紫衫醇联合顺铂治疗106例晚期非小细胞肺癌的临床疗效和安全性。方法脂质体紫杉醇135 mg/m2,静脉滴注第1天,顺铂60mg/m2,静脉滴注第1~3天,21 d为1个周期,至少治疗2个周期。结果完全缓解(CR)19%,部分完全缓解(PR)16%,病情稳定(SD)43%,病情进展(PD)22%。主要毒性反应为白细胞下降和脱发、胃肠道反应。结论脂质体紫杉醇与顺铂联合治疗晚期非小细胞肺癌有较好的临床疗效,耐受性好。
Objective To observe the clinical efficacy and safety of domestic liposomal taxol combined with cisplatin in the treatment of 106 patients with advanced non-small cell lung cancer. Methods Liposome paclitaxel 135 mg / m2, intravenous infusion on the first day, cisplatin 60mg / m2, intravenous infusion of 1 to 3 days, 21 d for a period of at least 2 cycles. Results Complete response (CR) 19%, partial response (PR) 16%, stable disease (SD) 43%, progression of disease (PD) 22%. The main toxicity is leukopenia and alopecia, gastrointestinal reactions. Conclusion The combination of liposomal paclitaxel and cisplatin in the treatment of advanced non-small cell lung cancer has good clinical efficacy and good tolerability.