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近年来,国内外有关高血压病的研究进展很快,涉及流行病学、病理生理、细胞生物学、遗传、药理及临床等众多方面,尤其就高血压病的发病机理提出了一些新的观点,在治疗方面也推出了数种新型抗高血压药物。本文就高血压病的诊治近况作一简述。发病机理 (一)中枢与交感神经系统的作用中枢及交感神经系统通过其末梢分泌的儿茶酚胺而影响血压。血浆儿茶酚胺主要包括肾上腺素与去甲肾上腺素,前者占20～30%,后者占70～80%。前者来源于肾上腺髓质,后者代表受体部位具有生理活性的去甲肾上腺素量,可作为反映交感神经系统调节血压的指标。尿儿茶酚胺受各种因素的影响,不宜作为反映交感活动的指标。此外,血压升高与受体对儿茶酚
In recent years, the research on hypertension in China and abroad has been progressing rapidly, involving many aspects such as epidemiology, pathophysiology, cell biology, genetics, pharmacology and clinical research, especially some new opinions on the pathogenesis of hypertension , Also introduced several new antihypertensive drugs in the treatment area. This article gives a brief review of the diagnosis and treatment of hypertension. Pathogenesis (A) the central and sympathetic nervous system Central and sympathetic nervous system through its peripheral secretion of catecholamines affect blood pressure. Plasma catecholamines include epinephrine and norepinephrine, the former accounted for 20 to 30%, the latter accounted for 70 to 80%. The former is derived from the adrenal medulla, which represents the physiologically active norepinephrine at the receptor site and can be used as an indicator of sympathetic nervous system regulation of blood pressure. Urinary catecholamines affected by various factors, should not be used as an indicator of sympathetic activity. In addition, blood pressure is elevated with receptors on catechins