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目的:探讨乳腺癌术后胸壁复发的临床特征、治疗方法、预后情况。方法:收集2004年1月—2014年6月新疆医科大学附属肿瘤医院收治的113例乳腺癌术后胸壁复发患者的临床资料,分析各项因素与患者生存期的关系。结果:患者胸壁复发后生存期5~102个月,中位生存期41个月;1、2、5年生存率分别为100.0%、85.0%、38.0%。单因素分析显示,肿瘤大小、淋巴结转移状况、TNM分期、激素受体表达、HER-2受体表达、术后放疗、靶向治疗、内分泌治疗、胸壁复发前无病生存时间、复发灶的手术切除和放疗与乳腺癌胸壁单纯复发患者的生存期有关(P<0.05);多因素分析显示,TNM分期、激素受体表达、HER-2受体表达、靶向治疗、胸壁复发前无病生存时间是胸壁复发后生存期的独立预后因素。结论:乳腺癌术后胸壁复发的预后相对较好,综合治疗可能有助于提高治愈率。
Objective: To investigate the clinical features, treatment and prognosis of chest wall recurrence after breast cancer surgery. Methods: The clinical data of 113 patients with chest wall recurrence after breast cancer surgery collected from January 2004 to June 2014 in Cancer Hospital of Xinjiang Medical University were collected to analyze the relationship between various factors and patient survival. Results: The survival time of patients with chest wall recurrence ranged from 5 to 102 months with a median survival of 41 months. The 1-, 2-, and 5-year survival rates were 100.0%, 85.0% and 38.0%, respectively. Univariate analysis showed that tumor size, lymph node metastasis, TNM stage, hormone receptor expression, HER-2 receptor expression, postoperative radiotherapy, targeted therapy, endocrine therapy, disease-free survival time before chest wall recurrence and recurrence (P <0.05). The multivariate analysis showed that TNM staging, hormone receptor expression, HER-2 receptor expression, targeted therapy, and no recurrence of chest wall before disease recurrence Time is an independent prognostic factor for survival after chest wall recurrence. Conclusion: The prognosis of chest wall recurrence after breast cancer surgery is relatively good, and comprehensive treatment may help to improve the cure rate.