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目的：探讨抗结核药物所致药物性皮疹的常见类型、常见的致药物以及发生过敏的预后。方法研究2013年1月~2015年4月在我院住院抗结核治疗过程中发生药物性皮疹的85例结核病患者,分析导致药物性皮疹的抗结核药物以及皮疹类型。结果有17人因各种原因未能明确致敏药物,最终明确致敏药物的为68人89例次,依次为：利福平(RFP)28例、盐酸乙胺丁醇(EMB)19例、吡嗪酰胺(PZA)15例、利福喷丁(RFT)9例、异烟肼(INH)7例、对氨基水杨酸异烟肼(DIP)4例、盐酸左氧氟沙星3例、加替沙星3例、丙硫异烟胺1例。有10例利福平过敏者未发生利福喷丁过敏,1例对利福平及利福喷丁均过敏。皮疹类型有荨麻疹型、红斑型、湿疹型、猩红热型、麻疹型、疱疹型、紫癜型等不同表现。结论抗结核药引起的过敏反应表现多种多样；发生皮疹的抗结核药物最多的是利福平,其余依次为盐酸乙胺丁醇、吡嗪酰胺、利福喷丁、异烟肼、对氨基水杨酸异烟肼,利福平与利福喷丁交叉过敏者较少；经停药抗过敏治疗预后良好。“,”Objective To study the the type of the medicine for al ergy induced by anti-tuberculosis drugs, and categories sequences of the sensitized drugs that induced drug eruptions, clinical features, consequences. Methods 85 patients with tuberculosis treated in the fourth hospital of Lianyungang from January 2013 to April 2015 who occur skin rashes after receiving anti-tuberculosis treatment. To study the the type of the medicine for al ergy, categories sequences of the sensitized drugs, clinical features and consequences. Results 17 patients can not be clearly induced drug hypersensitivity due to various reasons. 68 people in 89 cases ultimately defined by sensitive drugs, fol owed by rifampicin (RFP) in 28 cases, ethambutol hydrochloride (EMB) in 19 cases, pyrazinamide (PZA) in 15 cases, rifapentine (RFT) in 9 cases, 7 cases of isoniazid (INH), pasiniazid (DIP) in 4 cases, 3 cases of levofloxacin hydrochloride, 3 cases of gatifloxacin, protionamide 1 case. 10 cases were al ergic to ifampicin, but weren't al ergic to rifapentine. 1 cases was al ergic to both rifampin and rifapentine. There were dif erent types of skin rash, urticaria, erythema polymorphe, eczema eruption, scarlet rash, erythema polymorphe etc. Conclusion There were dif erent types of skin rash casued by anti-tuberculosis drugs. The incidence rates wre (from high to low) rifampicin, hydrochloride ethambutol, pyrazinamide, rifapentine, isoniazid, isoniazid aminosalicylate respectively. The cross al ergy of rifampin and rifapentine is less. The prognosis is excel ent after termimtion the anti-tuberculosis drugs and with anti-al ergic treatment.