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目的观察中西医结合治疗早期糖尿病肾病(DN)的临床疗效。方法将60例早期DN患者随机分为2组。对照组30例采用西医常规治疗,包括饮食控制、体育运动、降糖和抗血小板治疗,并口服缬沙坦分散片;治疗组30例在对照组治疗方法的基础上加服补肾活血散。2组均以12周为1个疗程,1个疗程后比较2组的临床疗效,尿微量白蛋白排泄率(UAER)、尿β2-微球蛋白(β2-MG)水平。结果治疗组总有效率为86.67%,对照组为63.33%,2组比较差异有统计意义(P<0.05);治疗后2组UAER与尿β2-MG均显著下降,与同组治疗前比较,差异均有高度统计意义(P<0.01),且治疗组下降程度更为显著,与对照组比较差异有统计意义(P<0.05)。结论补肾活血散能够显著降低早期DN患者的UAER、尿β2-MG水平,从而保护肾脏功能,延缓早期DN的进展。
Objective To observe the clinical efficacy of integrated traditional Chinese and western medicine in the treatment of early diabetic nephropathy (DN). Methods Sixty patients with early DN were randomly divided into two groups. Thirty patients in the control group were treated with conventional western medicine, including diet control, physical exercise, hypoglycemic and antiplatelet therapy, and oral valsartan dispersible tablets. The treatment group was given 30 tablets of Bushen Huoxue San on the basis of the control group. The clinical efficacy, urinary albumin excretion rate (UAER), and urinary β2-microglobulin (β2-MG) levels in both groups were evaluated after 12 weeks as a course of treatment. Results The total effective rate was 86.67% in the treatment group and 63.33% in the control group. The difference between the two groups was statistically significant (P <0.05). After treatment, the UAER and urinary β2-MG in the two groups were significantly decreased, The difference was statistically significant (P <0.01), and the treatment group decreased more significantly, compared with the control group, the difference was statistically significant (P <0.05). Conclusion Bushen Huoxue San can significantly reduce the levels of UAER and urinary β2-MG in patients with early DN, thereby protecting renal function and slowing the progression of early DN.