Carter 和Braeh(1977)曾报告恶性疟原虫Z(Zairian)株在体外长期培养不加新鲜红细胞能产生配子体的方法。占红细胞0.6%的成熟雌雄配子体,在红细胞浓度低于1%(v/v)的培养基内发育。在pH为8.0的小牛血清中可见雄配子体形成小配子。在每个试验中虽然都有成熟的雄配子体,但不易于见到配子形成。经培养证明Z株在培养中能产生许多 Carter and Braeh (1977) reported that long-term in vitro cultivation of P. falciparum strain Z (Zairian) without fresh erythrocytes produces gametocytes. Mature male and female gametocytes, which make up 0.6% of erythrocytes, develop in medium with red blood cell concentrations below 1% (v / v). Male gametocytes were found to form gametes in calf serum at pH 8.0. Although there are mature male gametophytes in each experiment, gamete formation is not easy to see. The strain Z strain has been shown to produce a lot in culture