无胆脂瘤的慢性化脓性中耳炎(CSOM)经耳局部或口服抗生素冶疗无效后,即行鼓室乳突手术是公认的常规处理方法。迄今,这种处理中有许多问题很少引起注意,诸如耳局部用药潜在的耳毒性作用;对常见病菌如绿脓杆菌尚无有效的口服抗生素;带有鼓 Cholestatic mastoidectomy is a common accepted treatment for chronic suppurative otitis media without cholesteatoma (CSOM) after topical or oral administration of antibiotic therapy is ineffective. To date, there have been many problems with this treatment that have drawn little attention, such as the potential ototoxicity of topical otitis media; no effective oral antibiotics for common pathogens such as Pseudomonas aeruginosa;