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通过观察２位肟化合物ＨＩ－６和ＨＧＧ－４２及它们的４位胎异构体对不同有机磷毒剂抑制的ＡＣｈＥ的重活化作用发现塔崩、梭曼、沙林等有机磷毒剂磷酰化的ＡＣｈＥ活性中心的构象可能存在着明显差异；又从变构剂Ｃ＿（１０）和丙吡啶对ＴＭＢ＿４重活化这几种毒剂磷酰化ＡＣｈＥ的影响中证实塔崩磷酰化ＡＣｈＥ活性中心构象与沙林、梭曼和ＶＸ３种毒剂磷酰化的ＡＣｈＥ明显不同。
By observing the reactivation of AChE inhibited by different organophosphate poisons by observing the oxime compounds HI-6 and HGG-42 of the 2nd place and their 4-digit isoforms, it was found that the organophosphate poisons such as Taban, Soman and Sarin were phosphorylated Of AChE active center conformation may exist significant differences; and from the role of allosteric agents C_ (10) and pyridine on the TMB_4 reactivation of several agents phosphorylation of AChE phosphorylated AChE confirmed that the activity of the tower collapse phosphorylation conformation and Sarin, soman and VX3 poison phosphorylated AChE significantly different.