论文部分内容阅读
采用在染色体标本上同时显示妹染色单体互换（ＳＣＥ）及Ｇ带带型的方法，对２０例鼻咽癌（ＮＰＣ）患者ＳＣＥ频率、细胞动力学、ＳＣＥ交换点的分布以及高发交换点与脆性部位、原癌基因的关系进行了分析。结果表明：ＮＰＰ患者的ＳＣＥ频率显著高于对照组（Ｐ＜０．０１），而细胞增殖率指数在患者和健康人间无明显差异（Ｐ＞０．０５）。ＮＰＣ患者中的１，２，３，４，５，７，８，１２，１３，１４，１６，１７号染色体的交换点次数显著高于对照组（Ｐ＜０．０５）。作者确定的１７个高发交换热点与脆性部位、原癌基因的重叠率为２９．４１％，说明ＮＰＣ患者的遗传稳定性差。该文还对ＳＣＥ交换点的分布与染色体结构的关系进行了讨论。
Using SCE and G-banding patterns on chromosome samples, the frequency of SCE, the distribution of SCE and the distribution of SCE in 20 cases of NPC were analyzed. And fragile sites, proto-oncogene was analyzed. The results showed that the frequency of SCE in patients with NPP was significantly higher than that in the control group (P <0.01). However, there was no significant difference in the index of cell proliferation among patients and healthy people (P> 0.05). The number of exchange points of chromosomes 1, 2, 3, 4, 5, 7, 8, 12, 13, 14, 16 and 17 in patients with NPC was significantly higher than that of the control group (P <0.05). The author identified 17 high-frequency hot spots and brittle parts of the exchange, the overlap rate of protooncogene was 29.41%, indicating that patients with NPC genetic stability is poor. The paper also discusses the relationship between the distribution of SCE exchange sites and the chromosomal structure.