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目的探讨吉西他滨+米托蒽醌+足叶乙甙(GME)方案诱导化学疗法(化疗)治疗复发难治性急性白血病的疗效。方法 2010年5月-2011年4月对20例复发难治性急性白血病应用GME方案化疗,以了解其有效性、毒副反应。结果随访7个月20例复发难治性白血病经过GME方案诱导化疗1个疗程后总反应率为50%,其中5例完全缓解,4例部分缓解,1例形态学完全缓解而血细胞计数未完全缓解,均无早期死亡患者。结论 GME方案可作为复发难治性急性髓系白血病的一种安全、有效的诱导化疗方案,值得临床尝试。
Objective To investigate the efficacy of gemcitabine + mitoxantrone + etoposide (GME) -induced chemotherapy (chemotherapy) in the treatment of relapsed and refractory acute leukemia. Methods From May 2010 to April 2011, 20 cases of relapsed and refractory acute leukemia were treated with GME regimen in order to understand its effectiveness and side effects. Results The follow-up of 7 months 20 patients with recurrent refractory leukemia after GME regimen chemotherapy induction of a course of 50% of the total response rate, of which 5 were completely relieved, 4 were partially relieved, 1 complete remission morphology and blood cell count is not complete Relief, no early deaths. Conclusions GME regimen can be used as a safe and effective induction chemotherapy regimen for relapsed and refractory acute myeloid leukemia. It is worth clinical trial.