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钙拮抗剂是本世纪六十年代末发展起来的一类新药,目前主要用于防治心血管系统疾病。近年来,人们逐渐注意到它们的中枢药理作用,国外文献陆续发表了钙拮抗剂的抗惊和抗癫痫作用,中国科学院药物研究所也报道了钙拮抗剂对学习和记忆的影响。我们的实验选用了二氢吡啶类的硝苯吡啶(N-ifedipine,简称NF)和氟桂嗪类的桂益嗪(Cinnarizine,简称Cin)进行了抗惊作用和镇痛作用的研究。我们通过动物实验,证实了NF和Cin的抗惊作用和镇痛作用,NF的作用比Cin要强。通过镇痛机制的分析实验,发现NF和C-in均能使脑内CGMP含量增高。CGMP含量
Calcium antagonists are a new class of drugs developed in the late 1960s, and are currently mainly used for the prevention and treatment of cardiovascular diseases. In recent years, people gradually noticed their central pharmacological effects, foreign literature has published anti-shock and anti-epileptic effects of calcium antagonists, Institute of Materia Medica, Chinese Academy of Sciences also reported the impact of calcium antagonists on learning and memory. Our experiments used dihydropyridine N-ifedipine (NF) and flunarizine cinnarizine (Cinarizine, referred to as Cin) for the anti-shock effect and analgesic effect. Through animal experiments, we confirmed the anticonvulsant effect and analgesic effect of NF and Cin, and the effect of NF is stronger than that of Cin. Analgesic mechanism analysis experiments found that NF and C-in can make brain CGMP content increased. CGMP content