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以往动物试验表明脑膜炎球菌外膜囊(OMV)a菌茵对小鼠具有免疫保护作用,且效果优于通常使用的纯化外膜蛋白(OMP)菌苗.为探讨OMV菌苗在人群中的免疫防御作用,作者对含B群脑膜炎球菌OMV的六价PorA菌苗进行了1期临床试验.作者采用重组DNA技术构建了2株B
Previous animal tests showed that the meningococcal outer membrane capsule (OMV) a strain of bacteria in mice immune protection, and the effect is better than the commonly used purified outer membrane protein (OMP) vaccine.To explore the OMV vaccine in the crowd Immune defenses, the authors conducted a phase 1 clinical trial of a six-valent PorA vaccine containing meningococcal serogroup B B. The authors used recombinant DNA technology to construct two B