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目的从临床和实验研究两方面探讨乳牙釉质发育缺陷与龋齿易感性的关系。方法选择１７６例３～８岁的低出生体重儿和早产儿，分析乳牙釉质发育缺陷与龋齿的相关性；将４颗自然脱落的釉质发育不全乳前牙用于釉质溶解度的研究，比较发育不全部位和正常部位釉粉的溶解度。结果临床研究发现乳牙釉质发育缺陷与龋齿的发生显著相关；乳牙釉质混浊和釉质发育不全分别与龋齿的发生显著相关。溶解度研究发现发育不全的釉质溶解度大，且达到平衡的时间短。结论釉质发育缺陷（釉质发育不全和釉质混浊）增加了牙齿对龋的易感性
Objective To explore the relationship between dental enamel defects and dental caries susceptibility from both clinical and experimental aspects. Methods A total of 176 low birth weight infants and premature infants aged 3 to 8 years were enrolled in this study. The correlation between deciduous enamel defects and dental caries was analyzed. Four enamel hypoplasia of spontaneous exfoliated anterior teeth were used to study enamel solubility. Solubility of glaze powder for all and normal parts. Results Clinical study found that the developmental defects of primary enamel were significantly associated with the occurrence of dental caries. The deciduous enamel opacity and enamel hypoplasia were significantly associated with the occurrence of dental caries. Solubility study found that poorly developed enamel solubility, and the balance of time is short. Conclusions Enamel developmental defects (enamel hypoplasia and enamel opacity) increase the susceptibility of teeth to caries