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目的探讨腹水胆固醇浓度在鉴别门静脉高压性与非门静脉高压性腹水中的临床意义。方法应用胆固醇氧化酶比色法对159例确诊病例的腹水及血液样本进行胆固醇浓度的测定,并对检测结果进行分析,其中包括门静脉高压性腹水81例,非门静脉高压性腹水78例。结果门静脉高压性腹水组腹水中胆固醇浓度为(0.61±0.55)mmol/L,非门静脉高压性腹水组腹水中的胆固醇浓度为(2.32±1.05)mmol/L,前者明显低于后者(P<0.01)。根据受试者工作特征曲线(ROC曲线),腹水胆固醇浓度诊断门静脉高压性腹水的敏感度为96%,特异度为98%。结论对于一些临床表现不典型、原因不明确的腹水患者,腹水中胆固醇浓度对于门静脉高压性腹水与非门静脉高压性腹水的鉴别具有一定的价值。
Objective To investigate the clinical significance of ascites cholesterol concentration in differential diagnosis of portal hypertension and non-portal hypertension ascites. Methods Cholesterol concentration was measured by cholesterol oxidase colorimetric method in 159 cases of ascites and blood samples. The results of the test were analyzed, including 81 cases of portal hypertension ascites and 78 cases of non-portal hypertension ascites. Results The level of cholesterol in ascites was (0.61 ± 0.55) mmol / L in portal hypertensive ascites and (2.32 ± 1.05) mmol / L in non - portal hypertensive ascites, the former was significantly lower than the latter (P < 0.01). According to receiver operating characteristic curve (ROC curve), the sensitivity and specificity of ascites cholesterol in the diagnosis of portal hypertension ascites were 96% and 98% respectively. Conclusions For some patients with atypical clinical manifestations and unexplained ascites, the level of cholesterol in ascites has some value for differential diagnosis of ascites due to portal hypertension and non-portal hypertension.