采用低温包埋、胶体金标记、免疫电镜技术，进行了正常肝细胞和肝癌细胞内β－葡萄糖醛酸酶（β－Ｇｌｕｃｕｒｏｎｉｄａｓｅ，β－Ｇ）的定位研究。结果表明，β－Ｇ存在于内质网，溶酶体和高尔基复合体内，同时观察到肝癌细胞中标记β－Ｇ的金颗粒数目多于正常肝细胞中的数目。对肝细胞癌的早期发现，早期诊断可能具有意义。 The localization of β-glucuronidase (β-G) in normal hepatocytes and hepatoma cells was studied using low temperature embedding, colloidal gold labeling, and immunoelectron microscopy. The results showed that β-G was present in the endoplasmic reticulum, lysosomes and Golgi complex. At the same time, the number of gold particles labeled with β-G in liver cancer cells was observed to be greater than that in normal liver cells. Early detection of hepatocellular carcinoma may have implications for early diagnosis.