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目的:尝试采用序贯药物流产(药流)加缩宫素治疗,探讨缩短药流后阴道出血时间的方案。方法:将符合药流条件的109例患者随机分为观察组(56例)和对照组(53例)。观察组在应用序贯药流的同时肌肉注射缩宫素10 U,2次.d-1,共3 d;对照组不用缩宫素。观察药物流产当天、2周时B超宫腔回声不均区厚度及阴道出血天数。结果:两组当天B超宫腔回声不均区厚度比较差异无统计学意义(P>0.05);2周时B超宫腔回声不均区厚度比较差异有统计学意义(P<0.001)。观察组阴道出血≤14 d 39例,>14 d 17例;对照组阴道出血≤14 d 22例,>14 d 31例。两组阴道出血情况比较差异有统计学意义(P=0.003)。结论:序贯药流加缩宫素治疗能明显减少宫腔内残留组织,有效地缩短药流后阴道出血时间,提高药流后14 d内完全流产率。
Objective: To try to use sequential medical abortion (abortion) plus oxytocin treatment, to explore shorten the flow of vaginal bleeding after the program. Methods: A total of 109 patients were randomly divided into observation group (56 cases) and control group (53 cases). Observation group in the application of sequential drug flow, while intramuscular injection of oxytocin 10 U, 2 times .d-1, a total of 3 d; control group without oxytocin. Observed the day of medical abortion, 2 weeks when the uterine cavity echo uneven thickness and vaginal bleeding days. Results: There was no significant difference in the thickness of uterine echo between the two groups on the same day (P> 0.05). There was significant difference in the thickness of uterine echo between two groups at 2 weeks (P <0.001). Vaginal bleeding in observation group 39 cases, 14 days> 17 cases; control group, vaginal bleeding ≤ 14 days in 22 cases,> 14 days in 31 cases. There was significant difference between the two groups in vaginal bleeding (P = 0.003). CONCLUSION: Sequential medical ablation and oxytocin treatment can significantly reduce the residual tissue in the uterine cavity, effectively shorten the vaginal bleeding time after medical abortion and improve the complete abortion rate within 14 days after medical abortion.